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DxDirect
DxCollect
DxTerity’s genomic platform
1
CLPA Reaction
CLPA reaction converts each mRNA to a uniquely-sized ligation product at a 1:1 ratio.
2
PCR Amplification
PCR amplification—each gene is a unique size.
3
Readout
High throughput readout using ThermoFisher 3500Dx CE instrument.
CLPA-based testing platform offers direct-from-blood & tissue (including FFPE) testing of RNA
Lower cost and more scalable than qPCR/NGS for mid-plex (~60) gene expression analysis
Utilizes existing install base of ABI 3500Dx Genetic Analysers supported by Thermo-Fisher
6 hours sample to answer and up to 1500 samples per day/system
TAT 7 business days available
Analytical process
DxTerity has innovated across the analytical process. DxDirect’s unique workflow eliminates the need for sample purification, enabling high-throughput processing. This simplification is driven by the heart of the system, Non-Enzymatic Chemical Ligation.
This system uses uniquely sized, adjacently binding, chemically reactive probes (S-Probe and L-Probe) to target genes of interest. Upon binding to the RNA target, the adjacent probes spontaneously ligate and create reaction products which can be detected using industry standard instrumentation, such as PCR and capillary electrophoresis.
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Learn how our platform can support your diagnostic program.
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